Research has indicated that there are two distinct periods of accelerated aging in human life: at 44 and 60 years of age

A study has found that aging is not a gradual process but rather accelerates dramatically at certain ages. Researchers tracked 108 volunteers aged 25-75, collecting blood, stool, skin, mouth, and nasal swabs every few months for 1 to 7 years. By analyzing 135,000 molecules and microbes, they discovered that significant shifts in molecular and microbial abundance often occurred around ages 44 and 60. The first wave of changes was linked to cardiovascular disease and metabolism, while the second wave was associated with immune regulation, carbohydrate metabolism, and kidney function.

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